PRCD, or Progressive Rod-Cone Degeneration, is a type of inherited retinal disease that affects dogs. It is a form of Progressive Retinal Atrophy (PRA), a group of genetic disorders that cause the degeneration of the photoreceptor cells (rods and cones) in the retina, ultimately leading to vision loss and blindness.
Progressive Rod-Cone Degeneration is caused by a mutation in the PRCD gene, which affects the normal functioning of the photoreceptor cells. This disorder primarily affects the rod cells, which are responsible for low-light and peripheral vision and progresses to the cone cells, responsible for color vision and visual acuity. The progression of PRCD varies among breeds and individual dogs but typically begins with night blindness, followed by a gradual loss of peripheral vision, and eventually complete blindness.
To reduce the prevalence of PRCD in dog breeds, genetic testing is available to identify carriers of the mutation. We use these tests to make informed breeding decisions and avoid mating two carriers, as this can result in affected offspring.
There is currently no cure for Progressive Rod-Cone Degeneration, but affected dogs can still lead fulfilling lives with the right accommodations and support from their owners. It is essential to monitor the dog’s environment and ensure their safety as their vision declines.
